Self-Assembly of Large-Scale Shape-Controlled DNA Nano-Structures.

摘要

We proposed to develop a methodology by using short synthetic DNA strands to build complex DNA nano-structures. In such a methodology, each short synthetic DNA strand, called DNA brick, is designed as a modular building block to assemble large structure with nanometer scale geometry control. We are using the methodology to build a variety of complex nano-structures, including 1D, 2D, 3D discrete structures and extended crystals. We are also developing a number of real world applications based on these novel structures. The successful development of this modular nano construction methodology and the associated real world applications will have transformative impact.