Chemistry and Pharmacology of Long Term Potentiation: Contributions Beyond Synaptic Modification

摘要

Work from this laboratory demonstrated that receptors with integrity epitopes, and that bind to the consensus RGD (arginine-glycine-aspartate) sequence, are concentrated in forebrain synapses Light and electron microscopic immunocytochemical experiments from other groups then showed that Bi subunits are present in hippocampus and that x8 subunits are highly concentrated in hippocampal synapses. Having established that integrins are indeed located in adult synapses,it was appropriate to ask what subtypes are used by brain and to map their distributions across regions. The question is potentially of considerable importance because the type of outside-in signaling performed by integrins is affected by their subunit composition.