Novel Myc-Interacting Protein With Features of a Breast Tumor Suppressor Gene Product

摘要

This research project was founded on our discovery of the Bin1 gene, which encodes a novel adaptor protein (originally known as 99') that has tumor suppressor properties in breast cancer. Bin1 interacts with Myc, an oncoprotein widely activated in breast cancer, and mechanistic investigations in our laboratory suggests that Bin1 has a role in mediating apoptosis by Myc under certain conditions. This project exceeded its planned aims, including the following milestones. Characterization of the Bin1 gene and its multiple gene products allowed an intensive analysis of Bin1 structure and expression in 50 breast cancer cases and multiple breast cancer cell lines.