P27Kipl Tumor Suppressor and Multi-Step Tumorigenesis

摘要

The most common genetic alterations found in tumor cells are mutations in genes that regulate cell proliferation. We have recently discovered that p27Kipl, a protein that negatively regulates cell division, is a tumor suppressor gene and that its level of expression in human breast cancer is a powerful predictor of tumor aggression and patient mortality. This research proposal is designed to understand the role of p27 in tumorigenesis by combination of mouse models and immunostaining primary human breast cancer specimens to assess the p27/p130 interaction.