Characterization of the Mechanisms of IGF-I-Mediated Stress-Activated Protein Kinase Activation in Human Breast Cancer Cell MCF-7

摘要

Cumulative evidence shows that insulin-like growth factor (IGF-I) plays an important role in the mitogenesis of breast cancer cells. IGF-I stimulates cell division by regulating events during the early G1 phase, but little is known about the signal transduction pathways involved in these events. The purposes for this proposal are: (1) what is the role of protein kinase C in the IGF-I-induced SAPK/JNK activation in human breast cancer cells MCF-7.2. what is the relationship between IGF-I-induced SAPK/JNK signaling pathway and cyclic AMP-dependent protein kinase A signaling pathway.