DURIP: Center on Countermeasures Prevention of Human Performance Failure from Biological Vulnerability: Achieving Optimal Capability

摘要

This DURIP grant made possible major technological advances at the three sites of the AFOSR PRET Center (University of Pennsylvania, Harvard University and Stanford University), substantially improving the Center's capability to study the neurobehavioral and neurobiological deficits associated with sleep deprivation and jet lag, and the development of countermeasures, in the context of simulated sustained operations. At Stanford University, a state- of-the-art pre-clinical sleep- wake bioassay technology (SCORE-2000) was developed and employed for the clinically predictive testing of countermeasures in animals. At the University of Pennsylvania and at Harvard University, integrated systems for the on-line measurement of a range of physiological and neurobehavioral variables in humans were purchased, installed, tested and operationalized. Thus, from pre-clinical animal studies to application in human laboratory studies, the DURIP grant considerably streamlined and expanded the PRET Center's efforts to identify, evaluate and transition countermeasures to deficits associated with sleep deprivation and jet lag.