Control of Hemorraghic Hypotension With Gly-Gin, a Non-Opiod Beta- Endorphin Peptide

摘要

This project tested the hypothesis that Gly-Gin, a dipeptide synthesized from the opioid peptide beta-endorphin inhibits hemorraghic hypotension in laboratory animals and attempted to determine the physiological and receptor mechanisms of its action. Tests in laboratory animals indicated that Gly-Gin produced a dose-related inhibition of hemorraghic hypotension when injected immediately before blood withdrawal. It also elevated plasma norepinephrine suggesting that it raises arterial blood pressure in hemorraged rats by restoring sympathetic nerve activity. Thus, Gly-Gin is a potent antagonist of opioid and hemorraghic hypotension. This project will be continued at the PI's new location at the Albany College of Pharmacy in Albany, NY. Also included herein are the Annual Report Questionaire and Project Highlight for the period 1 June 98 to 31 May 99.