Effect of JP-8 Vehicle on Dermal Penetration of Hydrocarbon Components from Jet Fuel

摘要

Published data on the dermal penetration of hydrocarbon components from the widely used jet fuel JP-8 are analyzed. The log of the dermal penetration coefficient Kp was observed to have a linear dependence on lipophilicity as estimated from the log-octanol-water partition coefficient Ko/w (with slight dependence on molecular weight). This semi-empirical relation can be used to predict (estimate) Kp values for other JP-8 components. In contrast to the penetration of compounds form aqueous vehicle, the more lipophilic compounds penetrated the skin at a lower rate, consistent with results on the partitioning of compounds into the stratum corneum from different vehicles.