Obesity, Hormone Receptor Status, and Breast Cancer Occurrence and Survival in New Mexico Hispanic and Non-Hispanic White Women.

摘要

Over the past 30 years, breast cancer incidence rates among Hispanic women in New Mexico have doubled, and mortality rates have increased over 50%. The factors responsible for these trends are not currently understood. This post-doctoral training project was designed to investigate whether ethnic differences in body composition and tumor hormone receptor status contribute to differences in breast cancer survival among New Mexico women. Analyses completed in Year 2 utilized data from 1484 breast cancer cases from three population- based breast cancer cohorts in New Mexico. Results indicate that Hispanics experienced higher 5-yr. all-cause and breast cancer mortality, compared to non- Hispanic white women (NHW). Breast cancer and all-cause mortality was not significantly associated with body mass index (BMI) when all three study cohorts were combined. Within the Prognosis Study cohort (n=650, 1996-99), total body fat and peripheral obesity measures were associated with negative estrogen receptor status among Hispanic patients only. In turn, estrogen receptor negative status was associated with increased breast recurrence rates and mortality. Tumor size was significantly associated with measures of centralized obesity among NHW patients only. Future research will continue to investigate factors associated with the ethnic differences observed in the relationships between body composition and breast cancer prognosis.