Bionic Approach to Cardiovascular Regulation: Bionic Arterial Baroreflex System.

摘要

A bionic system is an artificial device, integrated into natural human physiology by communicating with native regulatory system. This can functionally operate as if it were a part of the body. Bionic systems can be realized only with the knowledge of detailed characteristics of native system. We made use of 'white-noise approach' and have succeeded in functionally identifying the native arterial baroreflex. Using thus identified characteristics, we developed a bionic baroreflex system. Animal experiments in rats revealed that the bionic baroreflex system can stabilize pressure against hypotensive stimuli such as head-up tilt even without the native baroreflex system.