Evaluation of a Recoil-Escape Fiber Target Using 94Mo(p,n)94mTc to Produce 94TcO4- Precursor for Radiolabeled Compounds Useful in Positron Emission Tomography.

摘要

A variety of compounds radiolabeled with 99mTc(140 keV gamma T(sub 1/ 2)=6 hours) are widely used in nuclear medicine imaging. These compounds can also be radiolabeled using positron-emitting precursor 94mTcO4 (T(sub 1/2)=53 minutes) and used with Positron Emission Tomography (PET) to measure tissue concentrations in mu Ci/cm3, and produce kinetic data useful to understand the mechanism of drug action. This work-in-progress evaluates a novel accelerator target for producing 94mTc. Positron emitters have been produced with fiber targets, using the principle of recoil escape in which the target atoms are in a solid form, while recovering the product radionuclide ion by stopping it in a liquid or a gas. The recoil ion is transported out of the target, leaving the remaining target material to be used repeatedly in subsequent production runs. Our proposed target is based on this method.