Selective Stimulation and Measurement in the Cochlear Nucleus With the Spike Microelectrode Array.

摘要

Current prosthetic devices to restore hearing sense of patients with bilateral acoustic neuromas aren't always effective, because we don't have sufficient knowledge of the auditory pathways and the Cochlear Nucleus (CN) functions to stimulate the Cochlear Nucleus functionally. Our goals are to enhance our understanding of such functions and to develop effective stimulating strategies of the CN. In this paper, we fabricate the spike microelectrode array with 16-sites in 1.3mm-square area for stimulation and measurement of the CN and show its feasibility through rats' experiments. In the experiments, spatiotemporal responses in the CN are recorded with the electrode. Electrical stimulation at different sites with different current amplitudes exhibits different spatiotemporal patterns on the Auditory Cortex. These results will provide useful information to study the auditory pathways and the CN functions and to develop stimulating strategies.