Evidence for Central Venous Pressure Resetting During Initial Exposure to Microgravity.

摘要

We measured central venous pressure (CVP); plasma volume (PV); urine volume rate (UVR); renal excretion of sodium (UNa); and renal clearances of creatinine, sodium, and osmolality before and after acute volume infusion to test the hypothesis that exposure to microgravity causes resetting of the CVP operating point. Six rhesus monkeys underwent two experimental conditions in a cross- over counterbalance design: 1) continuous exposure to 10 head-down tilt (HDT) and 2) a control, defined as 16 h/day of 80 Degrees head-up tilt and 8 h prone.