Nuclear Factor-kappa B is Not Up-Regulated in Rat Pulmonary Tissue Following Sulfur Mustard (HD) Exposure

摘要

Vesicants, such as sulfur mustard (HD), pose an insidious threat to the respiratory tract. Exposure causes acute lung injury characteristic of an inflammatory response. Nuclear Factor-KAPPA B (NF- square B) is a redox sensitive transcription factor important in regulating genes involved in the inflammation. This study evaluated levels of NF-square B following exposure to HD. Male rats were euthanized at 3, 6, or 24 hr following intravenous HD or isopropanol (IPA controls) exposure. Nuclear protein samples extracted from pulmonary tissue were analyzed using an electrophoretic mobility shift assay.