Global Gene Analysis of Various Biological Threat and Infectious Agents Using PBMC: Implications for Therapy and Rapid Diagnostics.

摘要

Concerns relating to unidentifiable pathogens that could result from either deliberate or natural mutation processes have prompted studies to find alternative approaches other than the conventional detection methods. Our thesis was that an exposed individual would show gene expression responses unique to the pathogenic agent and prior to onset of the full illness. This study describes our work to establish a library of host responses to pathogenic agents for use to: (a) identify biological threat agents (b) predict the course of impending illness especially for unidentifiable pathogens (c) reveal new therapeutic targets. We demonstrate gene expression profiles unique to each pathogenic agent. The gene expression profiles of some agents preceded symptoms of impending illness.