Design and Synthesis of New Prostate Cancer Chemotherapeutic Agents.

摘要

This proposal is directed towards the development of new chemotherapeutic agents based on the mechanism of action of Taxol(TM). The recent discovery of two other natural products, epothilone, and eleutherobin, which operate by the same unique mechanism of action as Taxol(TM), i.e., microtubule stabilization, provides a unique opportunity for a collaborative approach to the elucidation of the pharmacophore common to these structurally dissimilar substances, using a combination of synthetic and computational studies. Such an advance could lead to the development of a novel family of prostate cancer chemotherapeutics.