Analysis of Changes in Auditory Nerve Signals Following Simulated Tinnitus for the Verification of Cochlear Model.

摘要

For an interpretation of the tinnitus phenomenon, reticular lamina which transmits energy in a cochlear was assumed as a mass and the components for the stiffness and control were added to the model even though it is perceived just as a thin layer. Then, animal experiment with guinea pigs was devised to evaluate the effect of tinnitus on the auditory nerves. Salicylate was introduced to the animal based on the Jastreboff's tinnitus model for the simulation of tinnitus conditions. It was found that the induction of salicylate caused the variations on the neural responses even without sound stimulation. Also, under the stimulation of sound with different frequencies, power contents varied in chronological order after the injection of salicylate. Parameters for the cochlear model could be extracted based on the results of this study. Moreover, protocols and the effect for the tinnitus treatment using electrical stimulation could be established.