In Vivo Validation of a One-Dimensional Finite Element Method for Simulation-Based Medical Planning for Cardiovascular Bypass Surgery.

摘要

Current practice in vascular surgery utilizes only diagnostic and empirical data to plan treatments, and does not enable quantitative a priori prediction of the outcomes of interventions. We have previously described simulation-based medical planning methods to model blood flow in arteries and plan medical treatments based oil physiologic models. These methods utilize computationally intensive three dimensional finite element analysis. We recently described a new method for simulation-based medical planning based on solving one-dimensional equations of blood flow. We demonstrate herein that these one- dimensional methods can be used to stimulate blood flow in a porcine thoraco- thoraco bypass and further that predicted flow rates compare favorably to in vivo data obtained using cine phase-contrast magnetic resonance imaging in four pigs.