Putative Nononcogene Addiction Gene Target and Marker for Radiosensitivity in High-Risk Prostate Cancer.

摘要

We proposed that RNASEH2A represents a novel type of gene, up-regulated in lethal prostate cancer to prevent catastrophic genomic instability and cell death and thereby acting to make prostate cancers resistant to treatment with radiation therapy. The major findings include (1) Expression of RNASEH2A in human prostate cancer cell lines. (2) Ability to modulate RNASEH2A expression genetically (3) Modulation of cell cycle, cell migration, transcription invasion and growth of prostate cancer cell lines with RNASEH2A. (4) Radio-resistance of prostate cancer cells that over express RNASEH2A. (5) Association of RNASEH2A with tumor grade. (6)Observation that RNASH2A expression does not independently predict lethal prostate cancer.(7)Observation that RNASH2A expression does predict radio-sensitivity and response to treatment in men who underwent radical prostatectomy and subsequently had post operative radiation.