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Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells.

机译：Brca缺陷细胞基因组不稳定性的分子机制。

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Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.

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Nussenzweig, A.;
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年度 2014
页码 1-82
总页数 82
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
CELLS(BIOLOGY); GENOME; MOLECULES; BREAST CANCER; DEOXYRIBONUCLEIC ACIDS; GENES; INHIBITION; INHIBITORS; INSTABILITY; IONIZING RADIATION; OVARIAN CANCER; PROTEINS; RECOMBINATION REACTIONS; 53BP1 GENE; BRCA1 GENE; BRCA2 GENE; CANCER BIOLOGY; CHEMORESISTANCE; CHEMOSENSITIVITY; DNA REPAIR; DNA(DEOXYRIBONUCLEIC ACIDS); DRUG SCREENS; ERFS(EARLY REPLICATION FRAGILE SITES); GENOMIC INSTABILITY; H2AX REGION; HOMOLOGOUS RECOMBINATION; MOLECULAR INHIBITORS; NON-HOMOLOGOUS END JOINING; PARP INHIBITORS; PHOSPHO-PROTEINS; PTIP; RIF1; SMALL MOLECULE INHIBITORS; TUMORIGENESIS;

机译：细胞（生物学）;基因组;分子;乳腺癌;脱氧核糖核酸;基因;抑制;抑制剂;不稳定性;电离辐射;卵巢癌;蛋白质;重组反应; 53Bp1基因; BRCa1基因; BRCa2基因;癌症生物学;化学抗性;化学敏感性; DNa修复; DNa（脱氧核糖核酸）;药物筛选; ERFs（早期复制脆性网站）;基因组不稳定性; H2aX区域;同源重组;分子抑制剂;非同源末端结合; paRp抑制剂;磷酸蛋白质; pTIp; RIF1;小分子抑制剂;肿瘤发生率;

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专利

1. Genomic instability in cultured stem cells: associated risks and underlying mechanisms. [J] . Ross AL, Leder DE, Weiss J, Regenerative medicine . 2011,第5期

机译：培养的干细胞中的基因组不稳定性：相关风险和潜在机制。
2. Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines. [J] . Mitsui J, Takahashi Y, Goto J, The American Journal of Human Genetics . 2010,第1期

机译：生殖细胞和癌细胞系中两个常见的脆弱位点相关基因座，PARK2和DMD的基因组不稳定性机制。
3. Genomic mechanisms and measurement of structural and numerical instability in cancer cells. [J] . Bayani J, Selvarajah S, Maire G, Seminars in cancer biology . 2007,第1期

机译：癌细胞的基因组机制以及结构和数值不稳定性的测量。
4. Thermally induced threshold voltage instability of III-Nitride MIS-HEMTs and MOSC-HEMTs: Underlying mechanisms and optimization schemes [C] . Shu Yang, Shenghou Liu, Cheng Liu, IEEE International Electron Devices Meeting . 2014

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5. Radiation-induced deregulation of PiRNA pathway proteins: A possible molecular mechanism underlying transgenerational epigenomic instability . [D] . Merrifield, Matthew. 2011

机译：辐射诱导的PiRNA途径蛋白的失调：跨代表观基因组不稳定性的潜在分子机制。
6. Mechanisms of Genomic Instabilities Underlying Two Common Fragile-Site-Associated Loci PARK2 and DMD in Germ Cell and Cancer Cell Lines [O] . Jun Mitsui, Yuji Takahashi, Jun Goto, 2010

机译：生殖细胞和癌细胞系中两个常见的脆弱位点相关位点PARK2和DMD的基因组不稳定性机制
7. Mechanisms of Genomic Instabilities Underlying Two Common Fragile-Site-Associated Loci, PARK2 and DMD, in Germ Cell and Cancer Cell Lines [O] . Mitsui, Jun, Takahashi, Yuji, Goto, Jun, 2010

机译：生殖细胞和癌细胞系中两个常见的脆弱位点相关位点PARK2和DMD的基因组不稳定性机制
8. Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells. [R] . Nussenzweig, A. 2014

机译：Brca缺陷细胞基因组不稳定性的分子机制。

Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells.

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