Role of DIP1, a Novel Id-Like Protein in Breast Cancer

摘要

We found that DIP 1, a novel 45 Kda nuclear protein recently identified in our laboratory, is frequently expressed in primary human breast cancers and breast cancer cell lines. However the level of expression 0 DIP 1 in breast cancer cells appears to be lower than that in normal mammary epithelial cells. Overexpression of DIP 1 in MCF-7 human breast cancer cells inhibited colony formation and cell proliferation but did not inhibit specific phases of the cell cycle. In mechanistic studies we found that DIP 1 inhibits the transcriptional activities of the cyclin Dl, c-fos, SRE, and NF Kappa B promoters.