Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells.

摘要

The long range goal of this laboratory is to identify integrin- associated signaling events that contribute to the constitutive migration of human breast cancer cells on the laminin extracellular matrix proteins. This project has shown that the heterotrimeric G-protein Galphai3 may link integrin activation and migration of MCF-lOA cells via a cAMP signaling pathway. The focus of the remaining work on this project is to identify how each integrin subtype which binds laminin-1 contributes to the regulation of this and other pro- migratory signaling pathways.