Structural Basis for the Role of CHK as a Tumor Suppressor Protein in Human Breast Cancer.

摘要

The goal of this project is to determine how CHK functions at the molecular level, crystals of the closed and purified, recombinant CHK SH2 domain will be obtained for X-ray diffraction studies from which we can determine its precise, three-dimensional, molecular Structure. Our research will focus upon the structural details of how CHK recognizes the tail of the active Her-2/neu receptor.