Derivation of Exposure Duration-Specific Occupational Exposure Limits (OELS) for 4,6-Dimethyl-2-Heptanone (CAS Number 19549-80-5).

摘要

Occupational Exposure Limits (OELs) were calculated for 4,6-dimethyl- 2-heptanone (CAS4 19549-80-5) using procedures established by the National Research Council (2001) for calculating Acute Exposure Guideline Levels. There were no appropriate toxicity data available for 4,6-dimethyl-2-heptanone to use in calculating OELs. 4,6-Dimethyl-2-heptanone is similar in chemical structure to 2-6-dimethyl-4-heptanone. The NOEL for 2-6-dimethyl-4-heptanone toxicity in rats of 125 ppm was used as a point of departure for estimating OELs for 4,6- dimethyl-2-heptanone. An total uncertainty factor of 300 was applied to the estimated NOEL to account for lack of toxicity information for 4,6-dimethyl-2- heptanone (UF1 = 10), uncertainty associated with extrapolating to humans from animal study data (UF2 = 10), and uncertainty of the existence of individuals within the population that may be very reactive to 4,6-dimethyl-2- heptanone exposure (UF3 = 3). The calculated OELs for 4,6-dimethyl-2-heptanone ranged from 1.8 ppm for a 5-minute exposure to 0.36 ppm for a 480-minute exposure.