Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planning and Tumor Prognosis.

摘要

This report presents the specific aims and accomplishments of our breast cancer research project during the second year of funding sponsored by the U.S. Department of the Army. It covers our activities from September 1, 2001 to October 31, 2002. Introduction The overall goal of this research project is to develop and evaluate a new approach to monitoring of oxygenated hemoglobin concentration (HbO2) of breast tumors under respiratory interventions using near infrared (NIR) spectroscopy and imaging techniques. Furthermore, we wish to compare and validate the optical method with concurrent measurements of tumor oxygen tension with the use of 19F EPI relaxation of hexafluorobenzene (HFB). Once we have rigorously established the integrated approach to tumor physiology, we will explore the influence of three interventions expected to modify tumor physiology. A better understanding of the interplay of these parameters in the natural history of a tumor could lead to enhanced therapeutic approaches and provide a novel diagnostic/prognostic tool for breast cancer research and clinical practice.