Quantitative, Noninvasive Imaging of DNA Damage in Vivo of Prostate Cancer Therapy by Transurethral Photoacoustic (TUPA) Imaging. Annual Report September 30, 2013-September 29, 2014.

摘要

The first year of this research program developed the foundation for a new medical imaging modality, now called Trans-Urethral Photoacoustic (TUPA) Imaging, which utilizing a small catheter into the urethra enabling imaging molecular marker of DNA Damage during prostate radiation therapy with high photoacoustic contrast and resolution. The development of this modality is significant to the tracking the biologic effect of radiation treatment, rather than just the physical dose. The work in Year 1 developed the imaging instrumentation to enable this modality. This grant has provided the funding to devise a trans-urethral photoacoustic endoscope, which has the potential to obtain higher resolution by using a high frequency ultrasound detector and achieve deeper penetration depth with a light delivery via the urethra. As part of the first-year training goals, this grant has provided the opportunity for extensive training in prostate cancer, molecular targeting of cancer, molecular imaging modalities, and opportunities to engage physicians to design appropriate tools. As of today, the results of this grant are: 2 journal publications, 4 conference abstracts, including 3 first author, and 2 conference oral presentations. The future for this grant looks bright, as this technique will soon be tested in small animal models in vivo; the next, more clinically feasible interventional version is under development