Cysteinyl Leukotriene Blockade Does Not Prevent Acute Mountain Sickness

摘要

MOUNTAIN sickness (AMS)is a syndrome that is characterized by headache, anorexia, nausea, vomiting, insomnia, lassitude, and malaise. There is individual variation in susceptibility to the syndrome; however, the hypoxia- induced symptoms are most common in unacclimatized low-altitude residents who rapidly ascend to terrestrial elevations exceeding 2,500 m (10). In addition, the development of AMS appears to be promoted by engaging in physical activities at high altitude (7). The symptoms of AMS commonly appear within 4 to 24 h of exposure, and usually resolve after several days as acclimatization to hypoxia is achieved. AMS is usually self-limited, but may progress into high altitude cerebral edema (HACE) or high altitude pulmonary edema (HAPE), both of which are potentially life threatening.