Mood and Vigilance Following Quercetin Supplementation

摘要

There is a high degree of military interest in the effects of specific nutritional constituents on cognitive function. This double-blind, placebo-controlled study was undertaken to test whether quercetin aglycone affects mood and vigilance in humans. Block randomization was used to assign 57 Department of Defense personnel into three groups. Based on group assignment, each subject received a one-time dose of 200 mg caffeine plus 1,800 mg placebo, 2,000 mg quercetin or 2,000 mg placebo 1 hour prior to completing a 45-minute scanning visual vigilance task. Profile of Mood States (POMS) questionnaires were completed prior to treatment and immediately following the vigilance test to measure change in subjective mood ratings. Caffeine and quercetin concentrations were measured in plasma samples collected 2-hours after treatment. The caffeine group significantly outperformed the placebo group with regard to correct detection of stimuli as well as reaction time during the vigilance task; no other groups were significantly different from one another.