Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland.

摘要

The funded proposal has not yet been activated at all sites. Approval was given to commence the research at the McGill University hospital site only. IRB approval was obtained from in Switzerland and Chicoutimi and we are working on obtaining the appropriate documents for the final review. Realistically, we anticipate that within the next 6 weeks, we will have obtained the documents needed for approval by Army. Prevalent cases were identified at all McGill University Hospitals (N=497). Treating physicians were contacted to obtain permission to contact their patients. 159 patients were contacted by letter and 93 responses were received. 77 had given consent to participate. 34 pedigrees have been drawn for cases and 3 for controls. 37 cases were shown Ishihara charts and results were recorded. 40 cases and 3 controls have donated their blood and 33 are scheduled to donate blood in the. DNA has been extracted from all blood samples of participants. We are still in the process of contacting patients and extracting DNA as we receive donations from patients. We will be meeting with three physicians who have not yet given permission to contact patients within the next month and will therefore be able to contact the balance of prevalent cases.