Hereditary Breast Cancer: Mutations Within BRCA1 and BRCA2 with Phenotypic Responses

摘要

From 85 hereditary breast cancer families, 285 invasive breast carcinomas from patients with known BRCA1/2 mutations were analyzed for histo- pathological features, c-erbB2, estrogen receptor (ER) and progesterone receptor (PR) expression This study confirms previous data showing that BRCA1 HBC displays an aggressive biological phenotype characterized by high S-phase fraction and low estrogen and progesterone receptor expression suggesting that BRCA1 breast cancer generally will not respond well to therapy with hormone receptor modulators such as tamoxifen.