Operation Brain Trauma Therapy.

摘要

Operation Brain Trauma Therapy (OBTT) is a multi-center pre-clinical drug screening consortium testing therapies in multiple animal models of traumatic brain injury (TBI) with the goal of identifying the best therapies for clinical trials. OBTT is also evaluating serum biomarkers of TBI across its models. Screening of therapies is carried out at three sites using three distinct rat models, i.e., parasagittal fluid percussion injury (FPI, University of Miami), controlled cortical impact (CCI, University of Pittsburgh), and penetrating ballistic-like brain injury (PBBI, WRAIR). The serum biomarkers GFAP and UCH-L1 are being serially assessed in all models (Banyan). Biomarker development is also ongoing in a large animal (micropig) FPI model (Virginia Commonwealth University) with parallel studies. The most promising drug will be tested in the micropig model to advance a therapy up the phylogenic scale. OBTT s work is ongoing as it completes year 3 of operation. OBTT is currently screening its 6th drug, has studied >900 rats, and assessed ~3000 biomarker samples.