Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions.

摘要

We already reported the synthesis of the amphiphilic PEG-b-(PAA)-b-P(HDFMA-co-MMA) copolymers that proved to encapsulate 1%-2% v/v PFP forming nanodroplets. We showed that NDs were able to ablate neighboring RBC as a model cells In this report, we investigated NDs ablation of prostate cells as well as the effects of ultrasound frequency on the pressure required to generate histotripsy cavitation bubbles and the resulting bubble dynamics. Results demonstrated complete fractionation and removal of cancer cells exposed to nanodroplet induced bubbles. These preliminary results support our hypothesis that ND-mediated histotripsy can be used for tumor ablation.