Mammographic Breast Density in a Cohort of Medically Underserved Women.

摘要

The purpose of this HBCU/MI Partnership Training Award is to train Meharry Medical College faculty to conduct independent breast cancer research by collaborating with faculty from Vanderbilt University Medical Center. Year 1 was a training year and during Years 2 through 4 a case-control study of obesity, insulin resistance and mammographic breast density is being conducted. Specific aims include: 1) to assess mammographic breast density through digital mammograms; for a sample of women we will also assess mammographic breast density through film mammograms to determine the diagnostic accuracy of digital versus film mammogram, 2) to obtain information on breast cancer risk factors including health literacy, and to collect anthropometric measurements and fasting blood, 3) to assay blood for select hormones and growth factors, 4) to perform statistical analyses to determine the associations between obesity and insulin resistance and mammographic breast density, and 5) to evaluate patients ability to understand their mammogram findings as they are explained by their medical provider. Drs. Sanderson, O'Hara and Khoder attended/presented at conferences and published a manuscript. Continuing institutional review board approval was obtained for the Mammographic Breast Density Project. Subject recruitment, data collection and processing, auditing quality assurance, and performing interim analyses were completed on 476 women.