Quantification of Lewisite in Air by Liquid Chromatography Mass Spectrometry (LC/MS)

摘要

It has been determined that lewisite will hydrolyze and oxidize under ambient conditions to form chlorovinyl arsonic acid (CVRA) which is an As+5 compound. Most published methods for the analysis of lewisite require the derivatization of lewisite with a dithiol compound to produce a compound that can be analyzed using a gas chromatograph. The derivatization methods generally have poor reproducibility and precision which is due to the fact that the CVRA compound will not be derivatized by the dithiol compound. The authors have established an air monitoring method that will account for both lewisite and CVRA sampled from the air during various sampling periods. Both lewisite and CVRA are extracted off a solid sorbent tube and analyzed by liquid chromatography/mass spectrometry.