Absorption, Distribution, and Clearanace o f2,6-Di-tert-Butyl-4- nitrophenol (DBNP)

摘要

NITROPHENOL, 2,6-Di-tert-butyl-4-Nitrophenol (DBNP) is a contaminant found on the interior surfaces of submarines. DBNP is produced when oil mist from synthetic steam turbine lubricants containing the antioxidant 2,6-Di-tert- butylphenol is nitrated during passage through the submarine air filtration system. US sailors may be exposed to OBNP for 24 hr/day for periods up to 6 months. While it is suspected that dermal and respiratory exposure to DBNP provides litte human risk due to its minimal solubility. Oral ingestion of DBNP in the food and water is a possible risk. For this reason, the present study measured the tissue distribution and clearance of radiolabeled DBNP in rats following a single oral gavage exposure in a 99.2% canola oil: 0.8% DMS0 vehicle. Groups of 12 rats were orally gavaged with either 15, 40 mg(exclamation point)kg DBNP. or vehicle. Two rats/dose were sacrificed from 1-10 days following the single exposure and 10 different organs immediately removed. Additionally, blood, urine and feces samples were collected from all rats as available. It was clearly demonstrated that orally dosed DBNP in a canola oil/DSMO vehicle is readily absorbed from the gastrointestinal tract, is differentially distributed to a wide range of organ compartments, and is cleared primarily through the feces.