Physical Properties of a Lavage Mixture of Pulmonary Surfactant, Perfluorodecaline, and Methylprednisolone (Perfactant Lavage)

摘要

Purpose: To characterize the physical properties of a lavage mixture of pulmonary surfactant, perfluorocarbon and methylprednisolone. Background: Perfluorocarbons (PFCs) are compounds derived from hydrocarbons by the substitution of hydrogen atoms with fluorine atoms. Perfluorocarbon liquids are colorless, odorless and biologically inert. They are highly dense, due to their molecular weight. Their low intermolecular forces give the liquids low viscosities (compared to liquids of similar boiling points), low surface tension and low heats of vaporization. PFC liquids are immiscible in most organic solvents, but are avid carriers of oxygen. The ability of PFC liquids to disperse readily throughout the lungs and allow for free gas exchange at the aveolar-capillary interface ( allowing subjects to 'breath') make these liquids ideal for delivering pharmaceutical agents to the lung and for whole lung lavage in certain disease states.