Novel High Resolution Positron Emission Tomography System for Measurement of Bone Metabolism

摘要

The purpose of the work reported here is to develop high-resolution PET instrumentation for imaging the long bones. To-date a single plane prototype and a single plane second-generation instrumentation have been completed and evaluated. A generalized multi-planar detector element has also been designed and evaluated experimentally and a volumetric instrument has been designed through simulation studies. Radiopharmaceuticals for bone growth rate imaging have been developed for use in a demonstration study of imaging in a monkey osteoporosis model. Preliminary animal studies showing feasibility have been carried out.