Neuroprotection from Brain Injury by Novel Estrogen

摘要

The present program of research aimed at determining the neuroprotective activity of novel estrogens in both male and female animal models for brain ischemic damage. We proposed to achieve 4 technical aims over the course of 3 years. These aims related to a description of the activity of several estrogens against cerebral damage induced by middle cerebral artery occlusion in a rodent model, when the estrogens were administered prior to or following the ischemic event. The present grant was immensely successful in achieving its technical objectives and in its productivity. During the 3.5 years of this grant, we published 27 full length technical papers, have 7 papers in press, have submitted an additional 14 manuscripts and have 5 manuscripts in preparation based upon the results of the studies proposed. Additionally, the research completed in this grant period has been described in 41 published abstracts. Collectively, these studies provided the knowledge that estrogen therapy and androgen reduction therapy are useful in protection of the brain tissue from damage related to the activities of U.S. Army male and female personnel.