Progesterone Receptor Isoform Influence on Human Breast Tumor Growth and Hormone Treatment.

摘要

Many postmenopausal women receive progestins in conjunction with estrogens as part of hormone replacement therapy. These women have a slightly higher risk of developing breast cancer than those receiving estrogen alone Progesterone mediates its affects through two known forms of the progesterone receptor, PR-A and PR-B. We aim to study how progesterone, via either PR-A or PR-B, influences estrogen-stimulated tumor formation and growth.