Development of a Novel Tissue Adhesive using a Naturally-Derived Small Molecule

摘要

A citric acid derivative (CAD) with three active ester groups in a molecule was prepared in order to develop a novel tissue adhesive consisting of CAD and collagen (CAD-C glue). The bonding strength of CAD-C glue to porcine soft tissues had high value similar to the tearing strength of the original soft tissue. The cytotoxicity of CAD for L929 fibroblast was 10 times less cytotoxic than that of glutaraldehyde and formaldehyde that are used in gelatin- resorcinol-formaldehyde glue. This adhesive developed will be applied as bonding reagent for soft tissues.