Effect of Angiogenic Growth on Tumor Growth, Vascular Function, and the Development of Hypoxic Therapeutic Resistance

摘要

The primary objectives of this grant were to determine the effects of either angiogenic growth factor overexpression or inhibition on mammary tumor pathophysiology. We evaluated four transfected human breast tumors and two murine mammary carcinoma lines by developing new methods for image analysis to quantify tumor vascular structure and function as well as micro-regional hypoxia. A particular emphasis was the comparison of several antiangiogenic strategies, including endostatin, anti-VEGFR-2, and Celebrex, to quantitate the pathophysiological response to each.