Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations 'Normal'. - An Immuno-Histopathological Study

摘要

After review of 140 files, a total of 90 prevalent cases of breast cancer were recruited from both clinical genetic services at the Montreal Hospital sites. A total of 36 cases were examined by three separate blinded pathologists for certain morphological and histological features to be compared among carriers and non-carriers of the BRCAl/2 genes. The pre-cancerous features that we focused on included apocrine hyperplasia, sclerosing adenosis, columnar alteration with prominent apical snouts and secretions(CAPSS) and usual ductal hyperplasia. We are now in the process of having the remaining 24 cases examined and reviewing the raw data to establish some results and conclusions. We hope to complete the examination of the remaining cases and the analysis of the raw data very shortly. Immunohistochemical analysis will follow.