Evaluation and Refinement of a System and a Method for the Use of Hyperspectral Imaging for Metabolic Monitoring

摘要

The primary hypothesis was that the mean grayscale intensity of hyperspectral oxygen saturation images in a region of interest (ROT) will change during hemorrhagic shock and during hypothermia. Secondary endpoints included the qualitative appearance of the ROT in the HST images, and a quantitative measure of tissue heterogeneity (including patterns of diffuse heterogeneity and mottling). The relationship of skin blood flow, of sympathetic nerve activity, and of catecholamine levels to these changes were also to be explored. Using the HSTMM methodologies developed for this study, it was possible to clearly differentiate (p << 0.01) between control and bleed groups in a porcine hypovolemia model. A stable hypovolemia model and data processing methods were developed to enable the transition of the technology and methodology into routine use at the Institute of Surgical Research. A pilot hypothermia study was performed, and HSTMM parameters were found to vary both with core temperature and skin contact temperature during hypothermia.