Investigate of the Candidate Tumor Suppressor Gene PLK3 in Prostate Cancer

摘要

On the basis of the observations that the PLK3 gene is down-regulated or mutated in certain prostate tumor cell lines, as well as other tumors (5;8;9) , we hypothesize that PLK3 is a tumor suppressor gene whose inactivation is an important event in the development of prostate cancer. We have proposed to characterize the genetic and epigenetic basis of aberrant PLK3 transcripts detected in prostate cancer, their prevalence and possible clinical relevance; to test the functional ability of PLK3 as a tumor suppressor gene, and to investigate the physiologic function of PLK3 by identification of proteins that interact with PLK3.