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Single-Molecule Detection of Proteins in Supported Bilayers: Applications in Device Fabrication and Sensor Technology

机译:支持双层膜中蛋白质的单分子检测:在器件制造和传感器技术中的应用

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摘要

Two single molecule fluorescent microscopes were designed and built for exploring membrane protein assembly. The first system, which was designed for use with solid supported membranes, is being used to explore the mechanistic details of alpha-hemolysin assembly. On the other hand, the second system was fabricated for use with blacklipid membranes. It is being employed to correlate ion channel insertion into bilayers with changes in current. The first results with these systems already show great promise.

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