Breast Cancer Risk in Relation to Serum IGF-1, IGFBP-3, and Their Genetic Determinants: A Study Within the European Prospective into Cancer (EPIC)

摘要

We are conducting a large case-control study nested within a prospective cohort, to estimate relative risks of breast cancer by serum levels of IGF-I and IGFBP-3, and to examine associations of polymorphisms in 15 candidate genes with levels of IGF-I, IGFBP-3, and cancer risk. Progress report: in the first two years of this project, 1084 breast cancer cases and 2116 control subjects were included in the study, and measurements of IGF-I and IGFBP-3 were (practically) completed. A first series of 23 SNPs were typed for all case and control subjects, and typing of 18 additional SNPs is ongoing. Major findings: Elevated serum IGF-I shows a moderate increase in breast cancer risk among postmenopausal women. Preliminary analyses also show significant associations of a number of SNPs and haplotypes with IGF-I, IGFBP-3, or breast cancer risk.