Toxic Interactions of Prophylactic Drugs and Pesticides

摘要

The goal of this project is to evaluate the mechanisms of interactive effects of exposure to the insect repellant, DEET, the insecticide, permethrin, and anti-nerve agent, pyridostigmine bromide (PB) and the biological and pathological consequences of such interactions. The hypothesis to be tested is that combined exposure to a mixture of chemicals would have enhanced, and in some cases detrimental toxicological effects than exposure with single chemical as result of diminished ability of the body to detoxify these chemicals, and as a consequence, an increased effective concentration of the parent compound(s) in the circulation. The resultant toxic response is probably due to enhanced delivery and availability of individual chemicals to the target organ, and to specific molecules.