Efficacy of the UK Recombinant Plague Vaccine to Protect Against Pneumonic Plague in the Nonhuman Primate, Macaca Fascicularis (PRIVATE).

摘要

The efficacy of the UK candidate plague vaccine was established in the cynomolgus macaque model for pneumonic plague. Animals were vaccinated intramuscularly on days 0 and 21 with either 40 g F1 + 40 g V or 80 g F1 + 80 g V in 0.5 ml 20% v/v Alhydrogel. They were challenged on day 60 with a lethal aerosol challenge (> 100 LD50) of CO 92 Y. pestis. All but one of the 19 vaccinated animals that were challenged survived.