Isolation and Characterization of Trioxyethylene-Encapsulated Gold Nanoclusters Functionalized with a Single DNA Strand.

摘要

A scalable means of isolating significant quantities of trioxyethylene-encapsulated gold nanoclusters (GNCs) labeled with a single DNA strand is demonstrated. Quantitative characterization of the product is obtained using UV-vis absorbance spectroscopy. These methods of isolation and characterization of singly functionalized GNC-ssDNA conjugates are expected to aid development of nanoscience applications that use DNA molecular recognition for guiding self-assembly.