DNA Vaccination to Overcome Peripheral Tolerance

摘要

The goal is to develop vaccination regimen to a tumor-associated self-antigen, ErbB-2 and to induce significant anti-tumor immunity in mice which are tolerant to ErbB-2. The objectives are to (1) Measure vaccination efficacy after depletion of CD4+CD25+ cells regulatory T (Treg) cells. (2) Compare immune reactivity and tumor growth inhibition in ErbB-2 transgenic mice vaccinated with autologous or heterologous ErbB-2 (3) Construct and test vaccination efficacy of ErbB-2 containing Pan DR Reactive Epitope (PADRE).